Cannabinoid system
by Bonnie Humphrey
1. Endogenous CB system
1.1. Receptors
1.2. Endogenous cannabiniods
1.2.1. Ligand 1: Anandamide
1.2.1.1. Hydrolyzed by FAAH
1.2.2. Ligand 2: 2-arachidonylglycerol
1.3. Enzymes
1.4. TRPs??
2. Exogenous cannabinoids
2.1. THC
2.1.1. Synthetic, hydrophilic analogue of THC: [3H]CP-55,940
2.1.2. Synthetic cannabinoid: HU-210 800x more potent than THC
2.2. CBD
3. Ways to detect ECS
3.1. Ligand assay
3.2. Behaviour assay
3.3. Genetic profiling
4. Cannabinoid signalling system
4.1. G protein coupled receptors
4.1.1. CB1 - in Brain cells
4.1.1.1. Antagonist "a substance which interferes with or inhibits the physiological action of another"
4.1.1.1.1. CB1 antagonist: SR141716A
4.1.2. CB2 - in Immune cells
4.1.2.1. CB2 antagonist: SR144528